The S.H.I.E.L.D. agent you've been demanding - Skye, a.k.a. Quake, a.k.a. Daisy Johnson - has only one ally she can turn to: her father, Mr. Hyde! Plus: Agent May and Mockingbird, together against a band of super-powered monstrosities! A commemorative 50th Anniversary story spanning the past and present! Howard the Duck, side-by-side with S.H.I.E.L.D.! Dominic Fortune, a hero from yesteryear resurrected to defeat an enemy from the past! And more!