Joe O'Brien is a Boston cop; his physical stamina and methodical mind have seen him through decades policing the city streets, while raising a family with his wife Rosie. When he starts committing uncharacteristic errors - mislaying his police weapon, trouble writing up reports, slurred speech - he attributes them to stress. Finally, he agrees to see a doctor and is handed a terrifying, unexpected diagnosis: Huntington's disease.
Not only is Joe's life set to change beyond recognition, but each of his four grown children has a fifty-fifty chance of inheriting the disease. Observing her potential future play out in his escalating symptoms, his pretty yoga teacher daughter Katie wrestles with how to make the most of the here and now, and how to care for her dad who is, inside, always an O'Brien. Inside the O'Briens is a powerfully true and tender elegy to the resilience of the human spirit.